Sheep antibody to LRRK2 (946-962): whole serum

Sheep antibody to LRRK2 (946-962): whole serum

S-070-100

Regular price $297.00 $260.00 You Pay

Supplier: Biosensis Catalog No#: S-070-100 Product Name: Sheep antibody to LRRK2 (946-962): whole serum Alternative Name: Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2; PARK8 Product Type: Polyclonal Antibody Description: LRRK2 is a member of the leucine-rich repeat kinase family. It role is yet unknown but it may play a role in the phoshorylation of proteins central to parkinson diseases. LRRK2 contains an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a mLK-like domain and a WD40 domain. LRRK2 is present in the cytoplasm but also associates with the mitochondrial outer membrane. Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8).ÀšÂ  Parkinson disease is characterised by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late-onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.
Size: 100 uL Host: Sheep Isotype: Mixed Applications: IHC, Frozen; Recommended Dilutions: IHC. A dilution range of 1:500-1:10000 is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. Clone Name: Conjugation: Formation: Lyophilized Immunogen: A synthetic peptide (LKRKRKILSSDDSLRSS; aa 946-962) as part of human LRRK2 protein conjugated to the Blue Carrier Protein has been used as the immunogen. Purity: Whole serum Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. Species Reactivity: This antiserum has been successfully tested in human. Other species have not yet been tested. Specification: Specificity for LRRK2 has been confirmed by IHC. | This antiserum has been successfully tested in human. Other species have not yet been tested. Shipping Conditions: 25°C (Ambient) Storage Conditions: After reconstitution keep aliquots at -20 ºC for a higher stability, and at 4 ºC with an appropriate antibacterial agent. Expiration Date: 12 months after purchase Datasheet Link: http://www.biosensis.com/pdf_datasheet.php?products_id=236 Product Link: http://www.biosensis.com/product_info.php/sheep-antibody-lrrk2-whole-serum-p-236