Sheep antibody to alpha synuclein (116-131): affinity purifiedS-075-50
Catalog No#: S-075-50
Product Name: Sheep antibody to alpha synuclein (116-131): affinity purified
Alternative Name: Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
Product Type: Polyclonal Antibody
Description: Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Size: 50 ug
Applications: WB; IHC, Frozen; IH(P), Paraffin embedded; IF, Frozen; IF(P), Paraffin embedded; ELISA
Recommended Dilutions: IHC, WB, ELISA. Recommended to be used at a concentration of 1µg/mL for immunohistochemistry (Paraffin sections); 0.5 µg/mL for WB and immunoblot. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Immunogen: A synthetic peptide (CMPVDPDNEAYEMPSEE) of human alpha synuclein protein (aa: 116-131) conjugated to diphtheria toxoid has been used as the immunogen.
Purity: Affinity purified and dialysed against phosphate buffered saline (PBS).
Reconstitution: Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material.
Species Reactivity: This antibody is known to react with alpha synuclein of Human, Mouse, Rat and other rodents.
Specification: This antiserum specifically detects alpha synuclein. | This antibody is known to react with alpha synuclein of human, mouse, rat and other rodents.
Shipping Conditions: 25°C (Ambient)
Storage Conditions: After reconstitution keep aliquots at -20 ºC for a higher stability, and at 4 ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiration Date: 12 months after purchase
Datasheet Link: http://www.biosensis.com/pdf_datasheet.php?products_id=51
Product Link: http://www.biosensis.com/product_info.php/sheep-antibody-alpha-synuclein-affinity-purified-p-51