Sheep antibody to alpha synuclein (108-120): affinity purified
Sheep antibody to alpha synuclein (108-120): affinity purified

Sheep antibody to alpha synuclein (108-120): affinity purified

S-078-50

Regular price $297.00 $260.00 You Pay

Supplier: Biosensis Catalog No#: S-078-50 Product Name: Sheep antibody to alpha synuclein (108-120): affinity purified Alternative Name: Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP Product Type: Polyclonal Antibody Description:
Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD). Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
Size: 50 ug Host: Sheep Isotype: Applications: IHC, Frozen; IH(P), Paraffin embedded; IF, Frozen; IF(P), Paraffin embedded; Recommended Dilutions: IHC. Recommended to be used at a concentration of 1 µg/mL for immunohistochemistry (Paraffin sections). Biosensis recommends optimal dilutions/concentrations should be determined by the end user. Clone Name: Conjugation: Formation: Lyophilized Immunogen: A synthetic peptide (PQEGILEDMPVDPC) of human alpha synuclein protein (aa: 108-120) conjugated to diphtheria toxoid has been used as the immunogen. Purity: Affinity purified and dialysed against PBS. Contains 0.02% sodium azide. Reconstitution: Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material. Species Reactivity: This antiserum is known to react with Human and Rat alpha synuclein. Specification: Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot. | This antiserum is known to react with human and rat alpha synuclein. Shipping Conditions: 25°C (Ambient) Storage Conditions: After reconstitution keep aliquots at -20 ºC for a higher stability, and at 4 ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles. Expiration Date: 12 months after purchase Datasheet Link: http://www.biosensis.com/pdf_datasheet.php?products_id=140 Product Link: http://www.biosensis.com/product_info.php/sheep-antibody-alpha-synuclein-affinity-purified-p-140