Anti-MDR3 Monoclonal Antibody
IHC621-100
Regular price
$210.00
You Pay
Supplier: GenomeMe
Description:
Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms’ tumor patients.
Specifications:
Clone | IHC621 |
Source | Mouse Monoclonal |
Positive Control |
Adrenal Cortex |
Dilution Range | 1:100 - 1:400 |
Figure: GeneAbTM MDR3 [IHC621] on Liver Cancer
References
- Hontecillas-Prieto L, et al. Oncotarget. 2017; 8:11173-86.
- van Helvoort A, et al. Cell. 1996; 87:507-17.
- Morita SY, et al. Hepatology. 2007; 46:188-99.
- Crawford AR, et al. J Clin Invest. 1997; 100:2562-7.
- de Vree JML, et al. Proc Natl Acad Sci U S A. 1998; 95.
- Rosmorduc O, et al. Gastroenterology. 2001; 120:1459-67.