DNASE1 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:25-100, ELISA 1:2000-5000
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: P24855
Gene Accession: BC029437
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Fusion protein of human DNASE1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.
Cellular Localization: Secreted. Nucleus envelope. Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-dnase1_polyclonal_antibody-36379.html
Manual Link: https://www.elabscience.com/viewpdf-36379-elabscience-E-AB-16984.PDF