Anti CTLA-4 Monoclonal Antibody
IHC004-100
Regular price
$145.00
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Supplier: GenomeMe
Description:Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a receptor on T Helper cells that functions as an immune checkpoint and downregulator of immune responses. Mutations in CTLA-4 are associated with insulin-dependent diabetes mellitus, Hashimoto’s thyroiditis, Graves’ disease, systemic lupus erythematosus (SLE), celiac disease, primary biliary cirrhosis, thyroid-associated orbitopathy, multiple sclerosis, and other autoimmune diseases. The spliced variant of CTLA-4 in SLE is present in the patient’s serum. Haploinsufficiency of CTLA-4 causes the immune system disorder known as CTLA-4 deficiency or CHAI disease (CTLA4 haploinsufficiency with autoimmune infiltration).
Clone | IHC004 |
Source | Mouse Monoclonal |
Positive Control |
Tonsil, Lymph Node, Thymus, Colon |
Dilution Range | 1:100 - 1:200 |
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