GeneAbTM MLH1 [IHC409] on Esophagus
Anti-MLH1 Monoclonal Antibody

Anti-MLH1 Monoclonal Antibody

IHC409-100

$65.00 You Pay

Supplier:  GenomeMe

Description:

MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.

Specifications:
Clone IHC409
Source Mouse Monoclonal
Positive Control Colon, Colon Carcinoma
Dilution Range 1:100 - 1:200
IFU & SDS:
References:
  1. Pal T, et al. Cancer. 2008; 113:733-42.
  2. Wright CL, et al. Am J Surg Pathol. 2003; 27:1393-1406.
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  4. Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
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  6. Hoedema R, et al. Am Surg. 2003; 69:387-92.
  7. Christensen M, et al. Cancer. 2002; 95:2422-30.
  8. Wahlberg SS, et al. Cancer Res. 2002: 62:3485-92.
  9. Lanza G, et al. Mod Pathol. 2002; 15:741-9.
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