Supplier: GenomeMe
Description:
MutS Homolog 6 (MSH6) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Studies have shown that mutations in MSH6, when co-indicated with mutations in MSH1 and MSH2, contribute to the development of sporadic colorectal carcinoma. Use of Anti-MSH2 is optimized when paired in an IHC panel with MSH6, MLH1, and PMS2.
Specifications:
Clone |
IHC006 |
Source |
Mouse Monoclonal |
Positive Control |
Colon, Colon Carcinoma |
Dilution Range |
1:100 - 1:200 |
References:
- Lagerstedt Robinson K, et al. J Natl Cancer Inst. 2007; 99:291-9.
- Niessen RC, et al. Gut. 2006; 55:1781-8.
- Hansen TP, et al. Appl Immunohistochem Mol Morphol. 2006; 14:115-21.
- Lawes DA, et al. Br J Cancer. 2005; 93:472-7.
- Stormorken AT, et al. J Clin Oncol. 2005; 23:4705-12.
- Rigau V, et al. Arch Pathol Lab Med. 2003; 127:694-700.
- Renkonen E, et al. J Clin Oncol. 2003; 21:3629-37.