Recombinant Mouse Poliovirus Receptor-Related Protein 2 Protein

Supplier: Elabscience Product Name: Recombinant Mouse Poliovirus Receptor-Related Protein 2 Protein Catalog No. PKSM041226 Product Type: recombinant protein Size: 50 ug Activity: Measured by its binding ability in a functional ELISA.1. Immobilized mouse CD112-His at 10 ?g/ml (100 ?l/well) can bind biotinylated mouse DNAM1-His with a linear range of 0.156-5.0 ?g/ml.2. Immobilized mouse CD112-His at 10 ?g/ml (100 ?l/well) can bind mouse DNAM1-Fc with a linear range of 0.03-1.0 ?g/ml. Protein Construction: Recombinant Mouse Poliovirus Receptor-Related Protein 2 is produced by our Mammalian expression system and the target gene encoding Gln32-Gly351 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Gly 351 Fusion Tag: C-6His Accession: NP_033016.3 Species: Mouse Expressed Host: Human Cells Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 35.6 kDa Applied MM: 40-45 kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of 20mM PB,150mM NaCl,pH7.4. Reconstitution: Please refer to it for detailed information. Background: Nectin-2( CD112) is a member of the nectin family, which contains two Ig-like C2-type domains and one Ig-like V-type domain in the extracellular region. Nectins are type I transmembrane glycoproteins that are calcium-independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs). Nectin2 is widely expressed in human tissues including brain, spinal cord, spleen, kidney, heart and liver. It can form trans-heterodimers with PVRL3/nectin-3 and interacts with CD226. Mutations of alleles of the murine CD112 gene can result in conditions such as morphologically aberrant spermatozoa. It may function in allergic reactions, and accordingly may used as a novel target for anti-allergic therapy.