Mouse Monoclonal Antibody to BCL-10

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse
Clone: 4F8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human BCL-10 expressed in E. Coli.
Formulation: Purified antibody in PBS containing 0.03% sodium azide.
MW: 26kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=34
Reference: 1. Willis, T.G., et al. (1999) Cell. 96, 35-45. ; 2. Lucas, P.C., et al. (2001) J. Biol.Chem. 276, 19012-19019. ; 3. Wang, L., et al. (2001) J. Biol.Chem. 276, 21405-21409 ;

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