Mouse Monoclonal Antibody to Apoa5 (bd)20005
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglyc erides, whereas a knock-in model with human ApoA5 produced 50–70% lower ; ; concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor-_ agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Recently, it was demonstrated that ApoA5 is present in human serum detected by polyclonal antibodies against both the NH2 and COOH termini, although at much lower concentration than other apolipoproteins.
Application: ELISA: 1/10000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human APOA5 (AA: 180-363) expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=36
Reference: 1. Pennacchio, L. et al. Science 2001 294, 169-173. ; 2. Prieur, X. et al. (2003) J Biol Chem 278, 25468-25480. ; 3. Obrien, PJ. et al. (2005) Clin Chem 51:2, 1-9. ;