Mouse Monoclonal Antibody to RB

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Application: ELISA: 1/10000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7E4B8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human RB expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=62
Reference: 1. Oncogene 19: 562-570. ; 2. Cell 81: 323-330. ; ;

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