Figure 1: Immunohistochemical analysis of paraffin-embedded human breast tissue (A), lymph tissue (B) and skin carcinoma (C), showing membrane localization using BLK mouse mAb with DAB staining.

Mouse Monoclonal Antibody to BLK

20085

Regular price $352.00 $299.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
Application: ELISA: 1/10000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 9D10D1;
Isotype: Mouse IgG2a
Immunogen: Purified recombinant fragment of BLK expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=105
Reference: 1. Theresa Tretter, Ashley E. Ross, Dominic I. Dordai. J. Exp. Med., Dec 2003; 198: 1863. ;