Figure 1: Western blot analysis using TYK2 mouse mAb against truncated TYK2 recombinant protein (1) and Jurkat cell lysate(2).

Mouse Monoclonal Antibody to Tyk2


Regular price $352.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8G8B3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of Tyk2 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
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Reference: 1. Michael H. Shaw, Gordon J. Freeman, Mark F. Scott. J. Immunol., Jun 2006; 176: 7263-7271. ; 2. Yohei Seto, Hiroshi Nakajima, Akira Suto. J. Immunol., Jan 2003; 170: 1077.

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