Mouse Monoclonal Antibody to PDGFR?20358
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFR? or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor ? (PDGFR?) and PDGF receptor ? (PDGFR?). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human, Mouse
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PDGFR? expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=338
Reference: 1. Biochem Biophys Res Commun. 1997 Jun 27;235(3):455-60. ; 2. Hum Pathol. 2005 Mar;36(3):242-9. ; 3. J Virol. 2007 May;81(10):5112-20.