Figure 1: Western blot analysis using ATP2C1 mAb against human ATP2C1 (AA: 119-269) recombinant protein. (Expected MW is 41.7 kDa)

Mouse Monoclonal Antibody to ATP2C1


Regular price $308.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey
Clone: 4G12;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 100kDa
Storage: 4C; -20C for long term storage
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Reference: 1. J Invest Dermatol. 2005 Nov;125(5):933-5. ; 2. J Dermatol Sci. 2006 Aug;43(2):150-1. ; 3. Dermatology. 2007;215(4):277-83.

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