Mouse Monoclonal Antibody to MAP2K2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Rat
Clone: 7F5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 44kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=409
Reference: 1. Mol Cell Biol. 1993 Aug;13(8):4679-90. ; 2. Eur J Biochem. 1995 Nov 15;234(1):32-8. ; 3. Oncogene. 1998 Jul 9;17(1):57-65.

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