Mouse Monoclonal Antibody to SNAI230037
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ?-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide. ;
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=437
Reference: 1. Biochem J. 2008 Dec 1;416(2):179-87. ; 2. Mol Biol Cell. 2008 Nov;19(11):4875-87. ; 3. Am J Pathol. 2009 Jun;174(6):2107-15.
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