Mouse Monoclonal Antibody to CDKN1B

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3D8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CDKN1B expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 22kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=444
Reference: 1. Exp Mol Med. 2009 Nov 30;41(11):765-71. ; 2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18. ;

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