Mouse Monoclonal Antibody to PTK7

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4F9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PTK7 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide. ; ;
MW: 118kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=478
Reference: 1. Oncogene. 1995 Nov 16;11(10):2179-84. ; 2. Cytogenet Cell Genet. 1997;76(1-2):43-4. ; 3. Biochem Biophys Res Commun. 2008 Jul 11;371(4):793-8.

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