Mouse Monoclonal Antibody to CD86

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.Tissue specificity: Expressed by activated B-lymphocytes and monocytes.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1B3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CD86 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 52kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=506
Reference: 1. Clin Exp Allergy. 2009 Dec;39(12):1852-6. ; 2. Am J Hum Genet. 2009 Nov;85(5):628-42. ; 3. Immunology. 2009 Nov;128(3):334-41.

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