Mouse Monoclonal Antibody to CSK30117
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Monkey; Rat
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CSK expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=516
Reference: 1. Nat Genet. 2009 Jun;41(6):677-87. ; 2. Leuk Res. 2009 Sep;33(9):e168-9. ; 3. J Hypertens. 2011 Jan;29(1):62-9.
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