Figure 1: Western blot analysis using KDM3A mouse mAb against Hela (1) and HepG2 (2) cell lysate.

Mouse Monoclonal Antibody to KDM3A


Regular price $308.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and ?-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1E12;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 147kDa
Storage: 4C; -20C for long term storage
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Reference: 1. DNA Res. 1998 Oct 30;5(5):277-86. ; 2. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. ; 3. Nature. 2005 Apr 7;434(7034):724-31.

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