Mouse Monoclonal Antibody to Oct4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5F7;
Isotype: Mouse IgG1
Immunogen: Synthesized peptide of human Oct4.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 45kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=546
Reference: 1. J Biol Chem. 2008 Dec 19;283(51):35825-33. ; 2. Dev Genes Evol. 2008 Oct;218(10):561-6. ; 3. Stem Cells. 2008 Sep;26(9):2419-24.

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