Mouse Monoclonal Antibody to CTCF

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey
Clone: 1D11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CTCF expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 83kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=548
Reference: 1. J Mol Med. 2008 Sep;86(9):1057-66. ; 2. J Exp Med. 2008 Apr 14;205(4):785-98. ; 3. EMBO J. 2008 Feb 20;27(4):654-66.

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