Mouse Monoclonal Antibody to MAP2K4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5H4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MAP2K4 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 42kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=567
Reference: 1. J Biol Chem. 2009 Jan 2;284(1):685-95. ; 2. J Immunol. 2008 Sep 1;181(5):3252-8.

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