Mouse Monoclonal Antibody to MSI2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 2C11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MSI2 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 35kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=577
Reference: 1. Am J Hum Genet. 2009 Nov;85(5):628-42. ; 2. Haematologica. 2008 Dec;93(12):1903-7.

Note: Highly recommend to send quote request for product availability and estimated shipping charge