Mouse Monoclonal Antibody to BLNK

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse
Clone: 5G9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human BLNK expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 68kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=631
Reference: 1. J Biol Chem. 2009 Apr 10;284(15):9804-13. ; 2. Cancer Sci. 2008 Dec;99(12):2444-54.

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