Mouse Monoclonal Antibody to RAF1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4G4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human RAF1 expressed in E. Coli. ;
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=724
Reference: 1. Am J Hum Genet. 2009 Nov;85(5):628-42. ; 2. Mol Cancer Res. 2009 Oct;7(10):1635-44. ;

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