Mouse Monoclonal Antibody to PPM1A

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey
Clone: 7F12;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli. ; ;
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 42.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=775
Reference: 1.Biol Psychiatry. 2011 Feb 15;69(4):360-5. ; 2.Cell Signal. 2009 Jan;21(1):95-102. ;

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