Figure 1: Western blot analysis using HAS2 mAb against human HAS2 recombinant protein. (Expected MW is 37.5 kDa)

Mouse Monoclonal Antibody to HAS2

30417

$341.00 You Pay

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/100 - 1/500
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4E7;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 63.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=816
Reference: 1.Cancer Res. 2012 Jan 15;72(2):537-47. 2.J Biol Chem. 2011 Sep 23;286(38):33632-40.

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