Mouse Monoclonal Antibody to STAT5A

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. ; ;
Application: ELISA: Propose dilution 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/50; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6D4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human STAT5A (AA: 583-794 ) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 90.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=822
Reference: 1.Cancer Res. 2011 May 15;71(10):3720-31. ; 2.Blood. 2011 Mar 24;117(12):3409-20. ;

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