Mouse Monoclonal Antibody to CD59

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/50 -1/200; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8D2B8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CD59 (AA: 31-111) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 14.2kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=828
Reference: 1.Cell Immunol. 2010;265(2):127-32. ; 2.Chin Med J (Engl). 2009 Sep 20;122(18):2123-8. ;

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