Mouse Monoclonal Antibody to PLAGL1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.  ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8D8C5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PLAGL1 (AA: 118-222) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 50.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3491
Reference: 1. J Biomed Sci. 2012 Nov 15;19:95. ; 2. Exp Cell Res. 2011 Dec 10;317(20):2925-37. ;

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