Mouse Monoclonal Antibody to CA9

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7C4A5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CA9 (AA: 37-186) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 49.7kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3506
Reference: 1. Breast Cancer Res Treat. 2012 Nov;136(1):67-75. ; 2. Histol Histopathol. 2011 Oct;26(10):1279-86. ;

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