Mouse Monoclonal Antibody to TFRC

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Monkey; Rat
Clone: 1A1B2;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 85kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3522
Reference: 1. Folia Histochem Cytobiol. 2012 Jul 5;50(2):304-11. ; 2. J Biol Chem. 2011 Oct 14;286(41):35708-15. ;

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