Mouse Monoclonal Antibody to PTP4A2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5B6F4;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human PTP4A2 (AA: 58-162) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 19.1kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3524
Reference: 1. Cancer Res. 2010 Nov 1;70(21):8959-67. ; 2. Blood Cells Mol Dis. 2010 Apr 15;44(4):209-14. ;

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