Mouse Monoclonal Antibody to ERBB4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5G6B4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ERBB4 (AA: 1159-1308) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 146.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3716
Reference: Neurosci Lett. 2012 Dec 7;531(2):209-14. ; EMBO Mol Med. 2013 Jul;5(7):1019-34. ;

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