Mouse Monoclonal Antibody to LDLR

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7H5B11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 95.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3733
Reference: Phytother Res. 2012 Nov;26(11):1688-94.; Biochim Biophys Acta. 2011 Jun;1811(6):397-408.;

Note: Highly recommend to send quote reqeust for estimated shipping charge including ice