Mouse Monoclonal Antibody to TERT

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3H2G9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 127kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3959
Reference: 1.Cancer Res. 2013 Dec 15;73(24):7162-7. ; 2.PLoS One. 2013 Sep 25;8(9):e75253. ;

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