Mouse Monoclonal Antibody to DNMT3B

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4D1A2E5;
Isotype: Mouse IgG2a
Immunogen: Purified recombinant fragment of human DNMT3B (AA: 1-150) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 95.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4003
Reference: 1.PLoS One. 2013 Jul 19;8(7):e69486. ; 2.Blood Coagul Fibrinolysis. 2012 Oct;23(7):636-9.;

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