Mouse Monoclonal Antibody to MMP14

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6A11D1;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MMP14 (AA: 112-246) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 65.9kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4018
Reference: 1.Cancer Med. 2013 Aug;2(4):457-67. ; 2.BMC Cancer. 2013 Feb 10;13:74.;

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