Mouse Monoclonal Antibody to HDAC4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5E4A5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human HDAC4 (AA: 456-592) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 119kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4020
Reference: 1.Cancer Res. 2013 Feb 15;73(4):1386-99. ; 2.Am J Hum Genet. 2010 Aug 13;87(2):219-28.;

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