Mouse Monoclonal Antibody to Notch3

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM:
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3E2D9;
Isotype: Mouse IgG2a
Immunogen: Purified recombinant fragment of human Notch3 (AA: 47-156) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 243.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4053
Reference: 1.Cancer Res. 2014 Jun 15;74(12):3282-93. ; 2.Int J Cancer. 2013 Dec 1;133(11):2577-86.;

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