Mouse Monoclonal Antibody to DNMT3L

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM:
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5H4A5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 43.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4138
Reference: 1.Clin Cancer Res. 2010 May 15;16(10):2751-9. ; 2.Epigenetics. 2009 Jul 1;4(5):322-9. ;

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