Mouse Monoclonal Antibody to UCP3

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: 1/200 - 1/1000; FCM:
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6B8C6;
Isotype: Mouse IgG2a
Immunogen: Purified recombinant fragment of human UCP3 (AA: 1-113 and 217-312) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 34.2kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4152
Reference: 1.J Biol Chem. 2011 Sep 16;286(37):32533-41. ; 2.Nutr Hosp. 2012 Jul-Aug;27(4):1190-5. ;

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