Mouse Monoclonal Antibody to BIN1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse
Clone: 3B6A4;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human BIN1 (AA: 189-398) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 64.7kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4200
Reference: 1.Trends Mol Med. 2013 Oct;19(10):594-603. ; 2.Mol Med. 2012 May 9;18:507-18. ;

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