Mouse Monoclonal Antibody to UHRF1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1A1B1;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human UHRF1 (AA: 616-755) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 91.3kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4275
Reference: 1.Biomarkers. 2015;20(3):183-8. ; 2.Med Oncol. 2013 Dec;30(4):613. ;

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