Mouse Monoclonal Antibody to ESR1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6A6F3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ESR1 (AA: 2-185) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 58.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4305
Reference: 1.Tumour Biol. 2015 Aug;36(8):6349-59. ; 2.Breast Cancer Res. 2014 Dec 12;16(6):494.;

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