Mouse Monoclonal Antibody to AXIN131208
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/50 - 1/250; FCM: 1/200 - 1/400; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human AXIN1 (AA: 546-752) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4358
Reference: 1.Cancer Lett. 2014 Dec 1;355(1):1-8.2.BMC Cancer. 2013 Aug 2;13:368.
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